With PPMS, the disease progresses steadily, with no remission. About 10% of people with MS are diagnosed with PPMS initially. Primary progressive MS (PPMS) is the most debilitating type of MS. The number of people who will progress to this stage is hard to determine because of the unpredictability of the disease. With SPMS, the remission between flare-ups is no longer present, and people with this type of MS generally have some symptoms at all times. ![]() For those people, SPMS is considered the second stage of the disease. Secondary progressive MS (SPMS) occurs in some people with RRMS.
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